Our immune cells can target trillions of different molecular patterns by rearranging their DNA and customizing themselves and the antibodies they produce. This DNA rearrangement is done by proteins known as RAGs, which move along chromosomes and cut and paste sections of genes.
Sometimes RAGs make mistakes, and genes can improperly turned on and contribute to the development of blood cancers such as leukemia, lymphoma, and myeloma.
Dr. Ba is figuring out how different DNA sequences lead to these mistakes, and is helping to lay the groundwork for future therapies to correct or contain this abnormal activity.
Projects and Grants
Mechanisms that mediate intra-locus and inter-locus regulation of V(D)J recombination at immunoglobulin light chain loci
Boston Children’s Hospital | Leukemia, Lymphoma | 2016 | Frederick W. Alt, Ph.D.
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