Ansuman T. Satpathy, M.D., Ph.D., CRI Lloyd J. Old STAR Stanford University and Gladstone-UCSF Institute of Genomic Immunology

There is still much we don’t know about the complexity of the immune system and its relationship with cancer. To improve our understanding so that we can better help patients, Ansuman Satpathy, M.D., Ph.D., a CRI Lloyd J. Old STAR at Stanford University School of Medicine and Stanford Cancer Institute and faculty member at the Gladstone-UCSF Institute of Genomic Immunology, is creating technologies to scan the entire genome and characterize the immune system’s fundamental properties in the context of cancer and immunotherapy.

To do so, Dr. Satpathy is refining single-cell sequencing and functional genomics technologies to study individual immune cells over time, with precision, in order to understand what regulates different lineages of immune cells and identify dysfunctional pathways that can arise in cancer. Additionally, he’s using synthetic biology tools to manipulate immune cells and determine the pathways that underpin behaviors like T cell exhaustion, so that better cell therapies can be engineered. Ultimately, Dr. Satpathy’s work should reveal important insights to aid both new and existing immunotherapy approaches.

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